Climate change continues to make a heavy toll on the agriculture sector in ASARECA member countries, putting years of economic progress at risk. Evidence shows that the impacts of climate change are being felt throughout the sub-region through rise in average temperatures, changes in rainfall patterns, increasing frequency of extreme weather events such as severe droughts and floods, and shifting agricultural seasons. The pathway to ensuring a climate-resilient agricultural sector must, therefore, be cemented with sound climate agricultural policies and interventions. Climate-Smart Agriculture is emerging as a promising pathway to address challenges imposed by the changing climate as it brings onboard a combination of policy, technology, practices and financing directly targeting and incorporating climate change adaptation and mitigation into the planning and implementation of agricultural initiatives.